Curious about the potential effects of vaping on your throat? Let's explore. Can vaping cause red sore throat? Yes, vaping can lead to a red and sore throat. The heat, chemicals, and irritants inhaled during vaping can cause inflammation and irritation, resulting in a red and painful throat. Proper hydration, reducing the vaping frequency, and seeking medical advice if symptoms persist can help alleviate and prevent a red sore throat caused by vaping.